Type 2 diabetes and obesity are both associated with non-alcoholic fatty liver disease (NAFLD) and
non-alcoholic steatohepatitis (NASH). NAFLD and NASH are currently underdiagnosed in clinical
practice.1 It is, however, important to evaluate liver fibrosis and identify patients at high
risk of liver disease progression as early as possible, in order to instigate appropriate management
plans.1,2
The Fibrosis-4 index (FIB-4) is a simple, non-invasive method of predicting hepatic fibrosis and has
been shown to be a prognostic marker of liver-related outcomes in NAFLD.1,3 FIB-4 is
calculated using a patient's age, liver enzymes and platelet count and provides a risk grading of either
low, intermediate or high.1 Online calculator ›
FIB-4 score <1.3: low risk of advanced fibrosis; 1.3-2.66: intermediate risk of advanced fibrosis;
≥2.67: high risk of advanced fibrosis1
References: 1. Vieira Barbosa J et al. Hepatol Commun 2022;6:765-779; 2.
Loomba R, Adams L A. Hepatology 2019;70:1885-1888; 3. Sterling R K et al. Hepatology
2006;43:1317-1325